▎ 产品简介
Prodoct Information |
Protein full name | Disks large homolog 4 |
Synonyms | DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse PSD95 |
Uniprot ID | Q62108 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Cell membrane, Cell junction |
Predicted MW. / Observed MW. | 95 kDa / 95 kDa |
Applications |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, cerebral infarction |
IHC/IF | Mouse, Rat | 1: 100-1: 200 | brain, cerebellum |
Storage |
Storage | Store at -20℃ | for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02% | sodium azide, 100 μg/mL BSA and 50% glycerol. |
▎ 背景
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
▎ 保存条件
-20℃保存
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